Arriving at court, the comedian did not speak to reporters and looked straight ahead as he entered the building.
He is accused of one count each of rape, indecent assault and oral rape, as well as two counts of sexual assault, relating to four separate women.
It follows allegations against him including that he raped a woman in a hotel room when she attended a Labour Party conference.
Brand is also accused of grabbing a TV worker’s breasts before dragging her into a toilet and orally raping her.
A radio station worker alleges Brand grabbed her by the face, pushed her against a wall and kissed her before groping her breasts and buttocks.
Another alleged victim accuses the comedian of indecent assault after he allegedly grabbed her forearm and attempted to drag her into a male toilet.
Russell Brand pleads not guilty to sex offence charges
The comedian and actor was charged by post last month with one count each of rape, indecent assault and oral rape, as well as two counts of sexual assault, relating to four separate women.
The allegations against Brand are said to have taken place against four women between 1999 and 2005.
The actor was charged following an investigation by Channel 4 and the Sunday Times in which several women made allegations against him.
He previously told his 11.2 million followers on X that he welcomed the opportunity to prove his innocence.
