Emergency services are on the scene between Grantley and Pateley Bridge, near Ripon, on Sunday afternoon (August 10).
North Yorkshire Police said the crash happened on a minor road near Skelding which will be closed for “some time”.
The force has urged drivers to avoid the area.
A police spokesperson said: “The road between Grantley and Pateley Bridge is currently closed and is expected to remain closed for some time.
“Motorists are advised to use an alternative route.”
