North Yorkshire Police said it happened around 12.30pm today (May 18) on the A661 Harrogate Road between Spofforth and the Kestral Roundabout.
A force spokesperson said: “It involved a black Peugeot 508 that was heading towards the A658 roundabout, and a black Lexus IS300 that was travelling towards Wetherby.
“The Lexus ended up down an embankment.
“The woman driving the Peugeot was airlifted to hospital with serious injuries.
“A woman passenger in the Peugeot was taken to hospital by ambulance for treatment.
“The man driving the Lexus was also taken to hospital for medical checks.
“The scene was closed to traffic with diversions to allow the emergency services to work safely at the scene.”
The force confirmed the road re-opened around 5pm today after diversions had been set up.
North Yorkshire Police said it is investigating the crash and has appealed for witnesses and those with dashcam footage to come forward.
Please quote reference NYP-18052025-0201 when providing details.
